Experiments with Dextran Sulphate as an Anticoagulant
نویسندگان
چکیده
منابع مشابه
The use of dextran sulphate as a blood anticoagulant in biological research.
Several well-known anticoagulants are in use for blood sample tubes, each having some special application, but there is little doubt that the naturally occurring anticoagulant, heparin, would find wider application were it not so difficult to prepare and consequently expensive. Chemically prepared sulphuric esters of polysaccharides are known to have anticoagulant action. One of these, dextran ...
متن کاملIn vivo and in vitro comparative assays of the anticoagulant activity of dextran sulphate and heparin.
Ophthalmological Society of the United Kingdom.Annual congress will be held on April 26-28, 1956, at the Royal Society of Medicine, London. The main subject for discussion will be "The Early Diagnosis of Glaucoma." Members wishing to contribute should notify the hon. congress secretary at 45, Lincoln's Inn Fields, London, W.C.2, not later than November 30. The annual dinner will be on April 26,...
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OBJECTIVES The ability to target conventional drugs efficiently inside cells to kill intraphagosomal bacteria has been a major hurdle in treatment of infective diseases. We aimed to develop an efficient drug delivery system for combating infection caused by Salmonella, a well-known intracellular and intraphagosomal pathogen. Chitosan-dextran sulphate (CD) nanocapsules were assessed for their ef...
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The structure of the natural anticoagulant, heparin, is gradually being elucidated. As each step forward is made, attempts to synthesize molecules with the biological activity of heparin receive renewed impetus. It is now known (Jorpes, 1939) that heparin is composed of glucuronic acid and glucosamine though the mode of linkage of these two parts is not yet clear. Some of the hydroxyl groups of...
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Persistent effects of a short course of intra-articular dextran sulphate, dextrans, or chondroitin sulphate were examined in rabbit knees. Only dextran sulphate produced gross arthritis, associated with high synovial acid phosphatase and beta-glucuronidase activities. Synovial degradative capacity in synovium-cartilage cocultures was increased 2-fold by dextran sulphate and 1.5-fold by chondroi...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of Medicine
سال: 1951
ISSN: 0035-9157
DOI: 10.1177/003591575104400710